Abstract :
Plan: A systematic review on the synthesis and biological activity of hydrazides and their derivatives.
Preface: The chemistry of hydrazide and its derivatives has obtained a great interest in both organic chemistry and biological science with remarkable impact. The development of novel organic compounds with antimicrobial, antiviral, anti-inflammatory, anti-tubercular, antibacterial, antifungal activities has been of great interest and pharmaceutical importance. Hydrazides and hydrazones are possessing an NHNH2 and NHN=CH- groups respectively. The availability of proton in hydrazides constitutes them as an important class of compound for new drug discovery. Therefore, researchers have shown great interest in developing these compounds as target structures for evaluating new biological activities.
Outcome: This review emphasises on various methods of synthesis and several biological activities possessed by hydrazide and hydrazone derivatives, which may help the researchers for the design and development of novel hydrazides as a potential candidate in pharmaceutical science.
Keyword :
Synthesis, Biological activities, Hydrazides, Hydrazone