Abstract :
Introduction and Aims: Numerous studies have suggested a possible relation between increased
homocysteinemia level and cardiovascular diseases. This relationship is clinically important in the
management of cardiac diseases specially in elderly population. However, there is limited data which
suggests association between hyperhomocysteinemia and hyperlipidaemia. The aim of this study is to find
a relation between hyperlipidaemia and hyperhomocysteinemia in patients who are not on lipid-lowering
treatment.
Materials and Methods: A total of 300 hyperlipidemic patients were enrolled who attended medicine
OPD. After obtaining informed consent, data were collected by a trained technician according to a standard
operating protocol of the laboratory. After an overnight fast of minimum 12 hours, 5 ml of venous blood
was taken under aseptic conditions in EDTA tube. The blood was late centrifuged, plasma samples were
then separated within half hour of sample collection and were stored at ????80 ?C in the laboratory. Total
cholesterol (TC), Low Density Lipid-Cholesterol (LDL-C), High Density Lipid-Cholesterol (HDL-C) and
Triglycerides (TG) were measured on Bene Sphera autoanalyzer. Homocysteine was measured on Robonic
ELISA reader.
Result: Homocysteine level in blood was directly proportional to increased level of TC, TG, LDL-C
and age of the patient. In the same group homocysteine level was inversely proportional to high density
lipoproteins.
Conclusion: There is strong correlation of increased homocysteine level with hyperlipidaemia.
Keyword :
Homocysteine, Hyperhomocysteinemia, Hyperlipidaemia, Total cholesterol, High density lipoprotein.