Abstract :
Background and Objective: Dengue fever is defined as a febrile individual who has travelled to or resides in a dengue-endemic area and has two clinical symptoms. Extrinsic incubation period changes are influenced by a number of variables, including the extent of daily temperature changes, virus genotype, and starting viral concentration. IL-10 may play a role in dengue pathogenesis by inducing an immune-suppressive function that results in IFN resistance, poor immunological clearance, and a long-term infectious impact for acute viral infections. The goal of this study is to learn more about the role of the cytokine IL-10 in dengue patients in order to get a better understanding of the disease, its treatment, and prevention in the coming years.
Materials and Methods: The research was conducted at the SGT Medical College Hospital and Research Institute in Gurugram, Haryana, in the Department of Microbiology. During the study's duration, 80 patient samples, 40 confirmed dengue-positive samples, and 40 healthy controls served as negative controls.
Result: A total of 40 dengue positive serum samples were analysed according to the severity of DENV infection into group 1 and we discovered that 90% of the samples represented non-severe dengue infection, while 10% of the samples represented severe dengue infection.
Conclusion: IL-10 is a post-anti-inflammatory cytokine that represents severity in dengue patients and has immune modulatory properties. This study further underlines the need to study and detect IL-10 in the early stages of severe dengue.
Keyword :
ALT, AST, Cytokines, Dengue, DENV- 5, Fever, Interleukins.