Abstract :
Background: CADRs are known to be more common in HIV with severity ranging from mild to life threatening ones.
Aims: a). To know the epidemiology and clinical profile of mucocutaneous manifestations of ADRs among HIV patients. b). To correlate the spectrum of mucocutaneous manifestations with laboratory derangements.
Materials and Methods: Adult HIV patients with suspected CADRs were recruited. History about epidemiological data, culprit drug and spectrum of mucocutaneous manifestations were taken. Severity scoring was done according to modified Hartwig and Siegels system and causality assessment was done using Naranjo system. Investigations like CBC, RFT, LFT, RBS, serum electrolytes, urine examinations were carried out.
Results: Out of 110 patients, male to female ratio was 0.83:1. Most common age group was 31-40 years. Most common presentation was maculopapular eruption (39.09%) followed by FDE (11.8%), angioedema (10.9%), DRESS (10%), SJS(7.27%) and others. Most common offending drug group was ART (40.9%) followed by antibiotics (20.9%). Most common laboratory derangement was increase in liver enzymes (SGOT in 24.5%, SGPT in 21.8%) followed by eosinophilia (19.1%), raised bilirubin and serum creatinine (5.5%). There was a significant association between raised liver enzymes, total bilirubin, Eosinophilia and
raised Serum creatinine with DRESS and also significant association between raised liver enzymes and raised Serum creatinine with SJS.
Conclusion: Prompt diagnosis, isolation of the offending drug and treatment of the CADRs are warranted, since severe reactions may be associated with internal organ damage.
Keyword :
Cutaneous Adverse Drug Reactions (CADRs), HIV, Laboratory derangements.