Abstract :
Sarcomatoid mesothelioma a rare variant accounts for 10-15% of malignant mesothelioma having a fatal
outcome. Therefore it becomes essential to differentiate sarcomatoid mesothelioma from other variants.
Morphologically it mimics malignant spindle cell tumor. Immunohistochemistry therefore becomes
mandatory to offer definitive diagnosis. However IHC markers also show overlapping expression, making
its interpretation difficult. In such challenging situations, clinicoradiological features, morphology together
with panel of IHC markers help to solve the riddle/dilemma. Here we report a case of sarcomatoid
mesothelioma with its varied IHC profile posing diagnostic challenge.
Keyword :
Sarcomatoid mesothelioma, Immunohistochemistry, Spindle cell tumors.