Abstract :
Diabetes mellitus (DM) is condition which is associated with metabolic diseases and considered as lifethreatening illnesses worldwide, characterized by sustained hyperglycemia. DM is linked with diabetes mellitus (especially type 2 diabetes mellitus) and carcinogenesis and biologically it is comprise with Hyperinsulinemia, hyperglycemia and fat-induced chronic inflammation in both diabetes mellitus and cancer, Organs such as pancreas, hepatic breast, endometrium, prostate and kidney are highly involved in the disorder, several medications are available on the market which decrease the risk and some of them raise the risk including metformin, a medication of choice for type 2 DM and its anti-neoplastic and tumor suppressant activities. Research has indicated that metformin shows great positive impact in various organs like breast, pancreas , liver, colon, ovaries and prostate tumors, Cytochromes P450s (CYPs) is the enzyme that catalyzes and aids in drug metabolism with its endogenous CYP substrates like eicosanoids, estradiol, arachidonic acids, cholesterol, vitamin D, and neurotransmitters. We review the role of CYPs in cancer of the renal and breast, and address their importance for atherosclerosis and type 2 diabetes mellitus.
Keyword :
Atherosclerosis, Cytochromes P450s, Diabetes mellitus, Hyperglycemia, Metformin.