Abstract :
Background: Propofol does not possesses the analgesic properties but is a safe anaesthetic agent for day care surgeries while ketamine is an excellent analgesic but has concerns regarding recovery. Fentanyl is a short acting potent opioid with pharmacokinetics suitable for day care anaesthesia. There are many short procedures in which you need procedural sedation with good analgesia and calm patient without need of intubation and relaxation. This study was conducted to compare and find suitable sedoanalgesia regime of TIVA using Propofol- Ketamine (Ketofol) or Propofol -Fentanyl (Fentofol) mixture infusion to facilitate comfortable and stable sedation experience with rapid recovery in short orthopaedic surgeries.
Settings and Design: Randomized, Double blind.
Patients and Methods: This prospective, randomized, double-blind study was conducted on 100 adult patients of age 20–55 years of either sex having ASA physical status I-II, posted for short orthopaedic procedures. Patients were assigned to receive slow bolus of fresh premixed injection of either ketofol or fentofol followed by TIVA infusion to a predetermined sedation level using Ramsay sedation scale. Haemodynamics, vital signs, side effects and recovery profiles were recorded.
Results: There was significant decrease (P
Keyword :
Propofol, Fentanyl, Ketamine, Ketofol, mixture infusion, Procedural sedation, PSA, TIVA