Abstract :
Systemic light chain amyloidosis is rarely linked to immunoglobulin A (IgA) monoclonal gammopathy, a rare plasma cell condition. The accumulation of misfolded immunoglobulin light chains causes AL amyloidosis, which impairs multiple organs. We describe a case of a male patient, age 66, who had weight loss and orthostatic hypotension. Subsequent analysis showed IgA monoclonal gammopathy with biopsy-proven AL amyloidosis, which affected the heart and nervous system. In order to avoid irreparable organ damage, this case emphasizes the difficulties in diagnosing IgA-associated AL amyloidosis and the significance of early detection.
Keyword :
IgA gammopathy, Monoclonal gammopathy of undetermined significance, Amyloidosis, Immunoglobulin