Abstract :
Background: One of the major hurdles in eradication of Tuberculosis is the development of Multi-drug resistant Tuberculosis, which needs timely identification and treatment to avoid its spread in the community.
Aim: The present study is an attempt to correlate demographic and clinical profile of multi drug-resistant tuberculosis cases coming to the facility
Setting and Design: A Hospital-based Cross-sectional Observational Study in Department of Respiratory Medicine, Smt. B.K. Shah Medical Institute and Research Center and Dhiraj Hospital, Vadodara, Gujarat.
Materials and Methods: Among subjects diagnosed as Multi-drug Resistant Tuberculosis over a period of one and a half years from May 2016 to November 2017. A detailed clinical profile physical examination and laboratory investigations were done and correlated with demographic profile.
Statistical analysis: Data was analyzed in Open source software OpenEpi. P value was considered to be significant at P
Results: Majority of patients were aged between 40 to 50 years with Male to female ratio was 1.5:1. Most patients were farmers, home makers (unemployed), and labourers and had a low education with lower socioeconomic status. The symptom profile indicated weight loss, loss of appetite, cough with expectoration, dyspnoea and fever. 70% of the patients had haemoglobin levels < or n=21;>
absence of an inflammatory condition. A major proportion of patients (n=24; 80%) had lymphocyte count > 20. The patients had high prevalence of co-morbidities.
Conclusions: Most of patients of multidrug resistant tuberculosis (MDR-TB)were 40 to 50 years of age with male predominance from lower socio-economic strata, had a low annual income and a positive history of tuberculosis. Multidisciplinary approach for the management of MDR-TB is needed.
Keyword :
Multi-drug resistant, Tuberculosis, Dyspnoea, MDR-TB.