Abstract :
Introduction: Proteinuria is a major component of preeclampsia. Urine protein measurement after 24-hour
urine collection is the traditional standard method for the detection of proteinuria. It is time-consuming.
As an alternative, spot sampling for a urine protein to creatinine ratio (PCR) ratio has been investigated.
Aim & Objectives: To determine the accuracy of the spot protein- creatinine ratio in comparison with 24
hours urine collection for detection of proteinuria in pre- eclamptic patients.
Materials and Methods: A hospital based prospective study was conducted with 120 patients to assess
the quantification of proteinuria in preeclamptic patient and comparing the two methods i.e. 24-hr urine
protein levels and random protein creatinine ratio conducted at tertiary care centre.
Results: There was a good positive statistical correlation between 24-hour total urinary protein level and
spot protein: creatinine ratio with a correlation coefficient (r) of 0.769.Conclusion: Random and spot urine
protein creatinine ratio can predict with high accuracy the amount of 24- hour urine protein excretion. The
urine PCR is reliable, relatively faster and accurate for proteinuria and can correlate well with 24-hour
urinary protein excretion which is gold standard.
Keyword :
Preeclampsia,Proteinuria, 24-hour urine collection, Spot urine PCR (protein to creatinine ratio)