Abstract :
Introduction: Postoperative nausea and vomiting (PONV) along with pain and shivering are frequently observed in patients recovering from surgery and general anesthesia.
Objectives: To compare the efficacy of Ramosetron alone and in Combination with Dexamethasone in patients undergoing laparoscopic surgeries, with respect to nausea, vomiting , requirement of rescue analgesia and antiemetics, discharge time, and also side effects.
Materials and Methods: Current study was a prospective observational double-blind study conducted at a tertiary care hospital. A total of 60 ASA grade I and II patients of age group 20-50 years undergoing elective laparoscopic surgeries under general anesthesia with Body mass index between 18-25 were included in the study. Participants were divided by using a computer-generated random number table into two groups of 30 each with Group R and Group RD each consisting of 30 patients. Group R received 0.3 mg. of Ramosetron intravenous (IV) and group RD received both 0.3mg. P value < 0>
Results: The mean duration of surgery in group R was 35.83 ± 6.44 minutes and 35.66 ± 6.26 minutes in group RD. The difference in the proportion of PONV scores between the study group was statistically not significant (P value 0.982). The rescue antiemetic was used in 5 (16.67%) patients in group R and in 2(6.67%) patients in group RD.
Conclusion: Combination therapy of Ramosetron with dexamethasone had better efficacy than Ramosetron alone in reducing PONV on patients undergoing laparoscopic surgeries.
Keyword :
Ramosetron, Ramosetron with dexamethasone, PONV, Laparoscopic surgery