Abstract :
Background : The treatment of pulmonary tuberculosis is quite challenging. The national tuberculosis
programs are shifting the trend to adopt daily regimen than the intermittent regimen. Hence, this study was
undertaken to study the effectiveness and adverse drug reactions of the daily and intermittent regimens.
Material and Methods : A retrospective study was conducted in the department of Chest and TB in
Basaveshwara Medical College and Hospital, Chitradurga and District Tuberculosis Centre, Chitradurga,
India. About 55 patients on daily regimen and 50 patients on intermittent regimen constituted the study
sample. The details regarding the age, sex, initiation and termination of the treatment, outcome and adverse
drug reactions were collected using a predesigned proforma.
Results : Majority of the patients in daily regimen were 56 – 65 years and intermittent regimen was aged
between 26 – 35 years. More number of the cases in both the regimen were males. Vomiting was the
main adverse drug reaction in patients on daily regimen and Abdominal pain in intermittent regimen.
About 54.5% of the patients on daily regimen and 62% on intermittent regimen were cured. The death
and defaulter rate was higher in patients on intermittent regimen.
Conclusions : Even though the cure rate is good in intermittent regimen, the adverse reactions are quite
high in this study.
Keyword :
Adverse drug reaction, Anti tubercular drugs, Pulmonary tuberculosis, Sputum smear.