Abstract :
Background: Prostatic carcinoma is the second most common cause of cancer deaths in men and the incidence is increasing significantly in recent years, due to early screening measures. A study designed to identify the prostatic lesions spectrum as per histopathological classification.
Materials and Methods: 50 prostatic lesion samples collected in 10% formalin were subjected to H and E stain and the mean AgNOR counts were calculated.
Results: Out of 50 specimens, 80% were benign and 20% belongs to malignancy. The mean age of patient’s benign and malignant lesions is 63.5 9.2 years and 69.5 8.5 years respectively (P=0.09). The most common clinical symptom of benign lesions was frequency in35 patients, followed by hesitancy and nocturia in 33 and 30 patients respectively. Serum PSA values above 10ng/ml were seen in 10 benign cases and 5 malignant cases (P=0.02). Out of 50 cases, 35 were BPH, 5 were non-specific granulomatous prostatitis, 8 prostatic adenocarcinoma, 1 case urothelial carcinoma and 1case with both prostatic adenocarcinoma and urothelial carcinoma were recorded. High grade PIN identified in 9 specimens and low grade PIN identified in 8 specimens. High grade PIN shows association with adenocarcinoma. Basal cell hyperplasia identified in 3 specimens. Tufting Pattern was observed in 2 specimens, flat Pattern observed in 4 specimens, and cribriform pattern observed in 1 specimen out of 9. Majority of patients diagnosed as conventional adenocarcinoma with a score of 9 (3 cases) followed by score of 8 (2 cases).
Conclusion: BHP is the most common non neoplastic prostate lesion, and commonly encountered in age group of 60- 70 years. In the current scenario, histopathological analysis of prostate specimens plays crucial role in both diagnosis and management.
Keyword :
Nodular hyperplasia, Basal cell hyperplasia, Adenocarcinoma prostate, Gleason’s score.