Abstract :
Background: Young adults face the issue of urinary tract infections as a common disease. Because of the increased
use of the fluoroquinolones, empirical therapy in the case of an uncomplicated infection of the urinary in the target
age group has also become controversial. Our research was also aimed at the nitrofurantoin efficacy, cotrimoxazole
and ciprofloxacin (trimethoprim-sulphamethaxazol); these are orally used drugs available in common.
Material & Methods: Our descriptive research was held in Services Hospital, Lahore (Microbiology Department)
in the time span of January – June, 2016. We included a total of 270 isolates of urinary tract infection selected from
outdoor and indoor respectively 132 and 138; culturing of the specimens was also carried out in the time span of the
research. We identified the isolates through conventional techniques with the help of API – 10 S. We also assessed
all the isolated for ciprofloxacin, nitrofurantoin and cotrimoxazole (trimethoprim-sulphamethaxazol) along with
related common antibiotics which are also used for the urinary pathogens.
Results: In the total sample of the research dominant isolated was E. Coli which was cultured in the 158 cases
(58.51%), after that the Klebsiella pneumonia in 48 cases (17.77%) & enterococcus spp respectively in 16 cases
(5.92%). The sensitive percentage in the outdoor cases (132) was observed as nitrofurantoin (92.4%), ciprofloxacin
(47.1%) and cotrimoxazole (62.1%); whereas in the indoor isolates (138) the respective sensitivity was observed as
84.0%, 34.7% and 28.9% respectively.
Conclusion: The effectiveness of the Nitrofurantoin is outdoor and indoor isolates is useful in the empirical urinary
tract infection which is not complicated.
Keywords: Nitrofurantoin, Cotrimoxazole, Ciprofloxacin, Trimethoprim-sulphamethaxazol, Urinary Tract
Infections and Urine.
Keyword :
Nitrofurantoin, Cotrimoxazole, Ciprofloxacin, Trimethoprim-sulphamethaxazol, Urinary Tract Infections and Urine.