Abstract :
The endothelial cells involved in modulating vascular tone and structure. Endothelial cells produce a vast range of
causes that also regulate cellular adhesion, smooth muscle proliferations and vessel wall inflammation. Endothelial
function is important for homeostasis of the body and its dysfunction is associated with several pathophysiology
conditions like diabetes, atherosclerosis. Sufferers with diabetes at all times exhibit an impairment of endotheliumdependent
vasodilation. Therefore, working out and treating endothelial dysfunction is the principle focus within the
prevention of vascular problems associated with all types of diabetes mellitus. This review will focus on the
pathophysiology, assessment and therapeutics that exceptionally target endothelial dysfunction within the context of
diabetic setting. Pathophysiology including nitric oxide, oxidative stress, angII, diabetes will be discussed.
Pharmacological approaches that upregulate endothelium derives nitric oxide synthase and treatment that might
prevent the development of diabetes associated vascular complications will be discussed.
Keywords: endothelial dysfunction, nitric oxide, nitric oxide synthase ,vascular smooth muscle cells, endothelialderived
hyperpolarizing factors.
Keyword :
endothelial dysfunction, nitric oxide, nitric oxide synthase ,vascular smooth muscle cells, endothelialderived hyperpolarizing factors.