Abstract :
The depletion of 17?-estradiol-2 (17?-E2) is one of the factors that cause the risk of rheumatoid arthritis (RA)
in females in the case of menopause. The aim of this study is to investigate whether the change in 17?-E2 levels
and interleukin 1-beta (IL-1?) is associated with menopause in RA women and whether there is a relationship
between them. 96 RA women were divided into three groups as follows: Group 1 (women of reproductive
age) – 30, Group 2 (premenopausal women) – 32 (menstrual or normal menstrual period without menstruation
for a period of not >6 months, and Group 3 (postmenopausal women) – 34 women in menopause (menopause
for at least 12 months). Serum levels of 17?-E2, IL-1?, and anti-cyclic citrullinated peptide were evaluated by
enzyme-linked immunosorbent assay. The results showed that a change in concentration of 17?-E2 resulted
in excessive production of IL-1? in women during reproductive age, premenopausal, and postmenopausal
compared to female control. Furthermore, there is a highly inverse correlation between IL-1? and 17?-E2 in
the serum of pre- and post-menopausal RA women. On the other hand, the study showed a positive correlation
between IL-1? and sex hormones 17?-E2 in women of reproductive age who suffer from RA. Moreover, the
study confirmed that the most risk factor is 17?-E2. The study showed that a lack of 17?-2 concentration after
menopause causes an increased concentration of IL-1? and this, in turn, stimulates the development of RA
disease during menopause. Menopause-associated 17?-E2 deficiency plays the major role in the pathogenesis
of RA
Keyword :
17?-estradiol, interleukin 1?, menopause, rheumatoid arthritis