Abstract :
Cisplatin is extensively used as a main chemotherapeutic drug for the treatment of many types of tumors. Cisplatin exerts excellent anticancer action, but its clinical use is frequently limited due to the development of severe side effects in the treated patients such as nephrotoxicity, anemia and bone marrow damage. Cytotoxicity of cisplatin is closely related to the generation of reactive oxygen species leading to oxidation of vital components of the cell (DNA) and genomic instability. Results and Conclusion: The results supported that the combination between curcumin and vitamin C (with more adjusted dose of vitamin C) exerted the best ameliorative effect against the cisplatin induction of micronucleated polychromatic erythrocytes.
Keyword :
Cisplatin; Vitamin C; Curcumin; Micronucleated polychromatic erythrocytes; Micronucleus test; Antioxidants