Volume :

8

Issue :

1

Abstract :

CADASIL (Cerebral Autosomal Dominant Arteriopathy with Sub Cortical Infarcts and Leukoenchephalopathy) is a rare autosomal dominant disease characterized by recurrent transient ischemic attacks, strokes, migraine, cognitive deficit and psychiatric symptoms which is associated with mutations in the NOTCH 3 gene on chromosome 19. Here we report a case that presented primarily to psychiatry with behavioral changes, migraine, aphasia, epilepsy and family history of stroke. The diagnosis was confirmed by the findings of brain Magnetic Resonance Imaging that revealed characteristic white matter lesions.