Abstract :
Introduction: Dermatophytosis is a common superficial fungal infection affecting keratinized tissues, with significant health and cosmetic impacts. Though itraconazole is widely used due to its broad-spectrum antifungal efficacy, its higher cost and adverse effects necessitate exploration of alternatives like ultramicrosized griseofulvin. This study aimed to compare the clinical efficacy, safety, and cost-effectiveness of oral itraconazole and oral ultramicrosized griseofulvin in the treatment of tinea corporis and tinea cruris.Materials and Methods: A randomized controlled trial was conducted over 24 months at Era’s Lucknow Medical College & Hospital. A total of 243 patients with KOH-confirmed tinea corporis or tinea cruris were randomly allocated into two groups: Group A (n=121) received oral itraconazole 100 mg twice daily, and Group B (n=122) received oral ultramicrosized griseofulvin 500 mg twice daily for six weeks. Clinical, mycological, and symptomatic evaluations were performed at baseline and at 2, 4, 6, and 8 weeks. p-values
Keyword :
Dermatophytosis, Itraconazole, Griseofulvin