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Article type :

Original Article

Author :

Priyanka Lakshman, Shilpa Borehalli Mayegowda, Sushma S Murthy, Manjula Nagalapur Gadilingappa, Priyanka Lakshman, Shilpa Borehalli Mayegowda, Sushma S Murthy, Manjula Nagalapur Gadilingappa, Priyanka Lakshman, Shilpa Borehalli Mayegowda, Sushma S Murthy, Manjula Nagalapur Gadilingappa

Volume :

11

Issue :

4

Abstract :

Introduction: Withlimited treatment options and emerging antimicrobial resistance amongst bacterial pathogens in hospital settings, the alarming conditionneeds to be addressed.Aim and Objective: The study aimed to determine the antibiotic susceptibility (AST) patterns, and extended spectrum ?-lactamases (ESBL) and Metallo ?- lactamases (MBL) production in Klebsiella pneumoniae and Acinetobacter baumannii isolated from respiratory tract infections (RTI).Materials and Methods: Current study, 1624 samples (sputum, tracheal secretions, suction tip) were collected during June 2020 to September 2022, phenotypically characterized by antibiotic sensitivity test (AST), Extended Spectrum Beta lactamases and Metallo Beta lactamases detection.Results: Of 12.3% (200 isolates), recorded prevalence rate of K. pneumoniae was 10.3% while, A. baumannii showed 1.9%. Following AST, K. pneumoniae displayed highest resistance against Ampicillin (95%), followed by Amoxycillin/clavulanic acid (91%), lowest recorded susceptibility for Tigecycline (39.2%). While, A. baumannii expressed susceptibility to Carbapenem group and Ciprofloxacin (84.3%), lowest Tigecycline (50%). Overall study exhibited Colistin retaining its activity with 100% sensitivity. ESBL production in K. pneumoniae was 31% and 0% in A. baumannii. While, MBL producers was 11 %, K. pneumoniae and A. baumannii recorded at 9.5% and 25% respectively.Conclusion: The increasing rates of ESBL producers is concerning, and the current study highlights use of Colistin as the best available antimicrobial for treating such RTI pathogens. Therefore, continuous monitoring of antibiotic-resistant profiles will help to guide effective antimicrobial therapy and management.