Abstract :
Introduction: Estradiol plays a key role in maintaining vaginal microbial balance, particularly by supporting Lactobacillus dominance. Hormonal shifts during menopause may disrupt this balance, increasing susceptibility to dysbiosis and related symptoms.Aim and Objective: This study aims to analyze the correlation between estradiol levels and vaginal microbiota patterns in menopausal and reproductive women.Materials and Methods: This cross-sectional study involved 59 women (29 menopausal and 30 reproductive-aged). Blood samples were collected to measure serum estradiol using ELISA, and vaginal swabs were analyzed via 16S rRNA gene sequencing. Correlations between estradiol levels and microbiota patterns were assessed using IBM SPSS Statistics Version 30.0.0.0.Result: Menopausal women showed significantly lower estradiol levels (4.0 vs 100.84 ng/mL, p
Keyword :
Estradiol, Dysbiosis, Menopause, Microbiota.