Abstract :
Background: One of the most common problems in both inpatient and outpatient settings is urinary tract infections (UTIs). It is crucial to continuously evaluate the pathogenic organisms and their antibiotic sensitivity due to the rise in antimicrobial resistance.Aim & Objective: To determine the types of bacteria that cause urinary tract infections and evaluate the patterns of antibiotic resistance in patients in a tertiary care facility in Pipariya, Vadodara, Gujarat.Materials and Methods: Patients having a clinical suspicion of UTIs were included in this observational study. Standard procedures were followed to collect urine samples, which were then processed for sensitivity testing and culture at the microbiology lab. According to CLSI recommendations, microorganisms and antimicrobial susceptibility were assessed using the automated Vitek Compact 2 system/ Kirby-Bauer disk diffusion technique (manual method).Results: Out of the 200 urine samples that were examined, 53 (26.5%) had considerable bacteriuria, whereas the remaining 147 (73.5%) had either no growth, mixed bacterial growth, or no pathogenic bacteriuria. Gram-negative bacteria were identified from the majority of the culture-positive samples. 43.9% of the positive isolates were E. coli, with Klebsiella pneumoniae (20.75%), Pseudomonas aeruginosa (11.32%), and Enterococcus spp. (9.43%), Acinetobacter spp. (7.55%), and other organisms, following in order of prevalence. The E. Coli isolates exhibited resistance to Ampicillin and Ciprofloxacin, but great sensitivity to Nitrofurantoin (92%), Imipenem (91%), and Amikacin (81%). Enterococcus and Staphylococcus aureus were among the gram-positive bacteria that were susceptible to Vancomycin, Linezolid, and Tigecycline.Conclusion: The study underlines most common E. coli is as a uropathogen and how crucial local antibiotic susceptibility data are for directing empirical treatment. Using antibiotics sensibly is essential to halting the emergence of new resistance.
Keyword :
Antibiotic Sensitivity pattern, Bacteriological profile, UTI.