Author :
Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube, Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube, Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube, Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube, Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube, Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube, Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube, Sabiha Naz, Tripti Saxena, Pawan Kumar Kare, Simmi Dube
Volume :
12
Issue :
3
Abstract :
Background: As a result of prolonged hyperglycemia in diabetic patients, glucose reacts with proteins non-enzymatically to produce Advanced Glycation End products (AGES) such as Pentosidine (PEN). These AGEs play a significant role in causing life threatening microvascular (diabetic retinopathy and diabetic nephropathy) and macrovascular complications in T2DM patients as stated by previous studies earlier.The present study is designed to evaluate the association of PEN with the development of vascular complications and how it can be useful as a surrogate marker for diagnosing these complications in T2DM patients.Materials and Methods: This case-control study was conducted between July 2024 to March 2025.246 T2DM cases (123 without & 123 with vascular complications) who attended the out- patient department (OPD) of Medicine were recruited and matched with 246 healthy, age and gender-matched controls. Baseline parameters (age, gender, duration of disease and BMI) were recorded and serum levels of PEN, Glycated Hemoglobin, FBG and PPBG were analyzed. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) version V30 and level of significance i.e p value
Keyword :
Pentosidine, Vascular complications, Surrogate marker.