Author :
Esther Udo Umoh, Godspower Oyubu, Bridget Kpoma, Festus Olayinka Daramola, Asimi Tawakalitu Temitope, Godspower Oyubu, Bridget Kpoma, Festus Olayinka Daramola, Asimi Tawakalitu Temitope, Esther Udo Umoh
Volume :
12
Issue :
2
Abstract :
Introduction: Stone breaker (Phyllanthus niruri (Linn.)) is a medicinal plant with long history of folkloric therapeutic use in the treatment of pathological conditions such as neurological diseases (Parkinson’s, Alzheimer, memory and learning disorder).Aim and Objectives: This study was designed to investigate the ameliorative potentials of stone breaker (Phyllanthus niruri (Linn.)) Leaf Extract (PLE) on Cold Restrain Stress (CRS)-induced neurological dysfunction in rat’s model.Materials and Methods: 25 Albino rats were divided into 5 groups of 5 wistar albino rats each, CRS method of induction were carried out for 3h/day for 7days followed by oral administration of PLE with doses of 100 and 200mg/kg BWT and 0.05mg/kg BWT of prazocin for 28days. In vivo inflammatory, excitatory, neuro- functional and behavioral indices were evaluated with the following assays; inflammatory assays (myeloperoxidase, TNF-?, IL-1?, IL-6 and xanthine oxidase), excitatory assay (Na /K ATPase) and neuro- functional assay (dopamine concentration and activities of acetylcholinesterase, tyrosine hydroxylase and NADH-Ubiquinone dehydrogenase (Complex I enzyme)). The behavioral indices (Y-maze task were determined on the rats to monitor the extent of cerebral alternation.Result: Tthis revealed that phyllanthus leaf extract (PLE) significantly (p
Keyword :
Stone breaker, Cold Restrain Stress, Medicinal plant, Neurological, Diseases