Abstract :
Background: Amblyopia, commonly known as “lazy eye,” is a developmental visual disorder characterized by reduced best-corrected visual acuity in one or both eyes, in the absence of any structural ocular abnormality. Recent studies have explored whether amblyopia is associated with changes in RNFL thickness or macular morphology, with conflicting results. Understanding these structural correlates of amblyopia could provide valuable insights into its underlying pathophysiology and may aid in the development of objective biomarkers for diagnosis and monitoring.Aim and Objective: To assess variations in retinal nerve fiber layer (RNFL) thickness and macular parameters in cases of unilateral amblyopia utilising spectral-domain optical coherence tomography (SD-OCT).Materials and Methods: A cross-sectional descriptive study has been carried out at the Department of Ophthalmology, Adichunchanagiri Institute of Medical Sciences, from March 2023 to September 2024. Seventy-five patients, 5 to 45years of age having amblyopia in one eye were involved. Best-corrected visual acuity (BCVA), RNFL thickness, refractive error, as well as macular parameters, were recorded with SD-OCT and were contrasted among amblyopic and fellow normal eyes.Results: Average age of participants was 12.5 ± 3.8 years, with a male predominance (56%). Amblyopic eyes showed significantly poorer BCVA (0.63 ± 0.15 logMAR) than fellow normal eyes (0.10 ± 0.05 logMAR, p
Keyword :
Amblyopia, Retinal nerve fiber layer thickness, Spectral-domain Optical coherence tomography, Visual acuity, Macular thickness.