Abstract :
Cardiac remodelling—structural, cellular, and molecular changes that reshape the heart after stress or injury—drives heart failure progression. In contrast, cardiac regeneration refers to the replacement of lost myocardium with new, functional tissue. Adult human hearts exhibit very low baseline cardiomyocyte renewal (
Keyword :
Cardiac remodelling, Cardiac regeneration, Reverse remodelling, Cardiomyocyte proliferation, Fibrosis, Hippo–YAP signalling, Stem cell therapy, Extracellular vesicles