Abstract :
The Myristica malabarica was estimated in the present study for antidepressant activity. The extraction was carried out by petroleum ether, chloroform, and ethanol. Pet-ether extract showed the presence of alkaloids, flavonoids, and triterpenoids. Chloroform extract showed the presence of alkaloids, glycoside, tannins& phenolics, saponins, flavonoids, carbohydrates, proteins & amino acids, phytosterols, and terpenoids. Ethanol extract showed the presence of alkaloids, glycosides, tannins& phenolics, saponins, flavonoids, carbohydrates, proteins & amino acids, and phytosterols. This activity was evaluated using the mice behavioral model i.e. forced swimming and tail suspension model for 14 days, with estimation of neurotransmitters in the animal’s brain. In depression, the brain reflected low monoamine levels like release of noradrenaline, dopamine, and serotonin but 14 days after successive administration of the ethanolic extract (100 and 200 mg/kg). Still, at a dose of 200mg/kg, it shows more potent antidepressant activity, and their levels were significantly increased. In conclusion, Myristica malabarica showed significant anti-depressant activity.
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