Abstract :
Floating tablets of Paliperidone were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the direct compression method, using polymers such as Tamarind Gum, Carnuba wax and HPMC K15 M. The Fourier transform-infrared spectra revealed that there was no interaction between polymers an drug; hence, they are compatible. The prepared tablets of all the formulations were evaluated for physical characters, hardness and friability, floating lag time, total floating time, drug content and in? vitro drug release. The in vitro release study of the tablets was performed in 0.1 N HCl as a dissolution media. In this research work formulation F5 fulfills all the testing parameters in terms of pre and post compression. And Optimised formulation was showed maximum drug release 99.13 % up to 12 hours. Floating lag time is less 21 sec and total floating time up 12 hours and it was fitted to kinetics of drug release for R2 value of Zero order release mechanism model is 0.979.
Keyword :
Paliperidone, Tamarind Gum, Carnuba wax, HPMC K15 M, direct compression method, floating lag time and total floating time