Abstract :
This review discusses contemporary research on solid lipid nanoparticles (SLNs) for encapsulation and delivery of
active and antioxidant compounds, encompassing various synthesis techniques and applications across multiple
fields. The development of SLNs begins with the choice of solid lipid matrices, emulsifiers/surfactants, and types
of active compounds or antioxidants, alongside synthesis methods and their respective applications. The lipid type
influences crystal morphology, active compound release kinetics, and encapsulation efficacy. Various fabrication
methods for SLNs can encapsulate both hydrophilic and hydrophobic antioxidants, each possessing distinct
advantages and drawbacks. The design of fabrication, which entails selecting lipid matrices, surfactants, and
fabrication techniques, critically influences SLN characteristics. High-shear homogenization paired with
ultrasonication emerges as the preferred method due to its simplicity and efficacy. A well-conceived fabrication
design yields SLNs that effectively stabilize active compounds and antioxidants, rendering them suitable for
diverse applications.
Keyword :
Insitu Gels, Solid Nano Particles, Solvent evaporation method, High Shier homogenisation.