Abstract :
Parkinson’s disease (PD) is a neurodegenerative disorder effecting both motor and nonmotor activities with symptoms like tremors, rigidity, bradykinesia and postural instability. Unusual clumps of the proteins were found in the brain of people with PD, scientist assume that they are the deposits of protein alpha-synuclein called Lewy bodies. The accumulation of alpha-synuclein as clumps in the neurons in some part of the brain prevents neurotransmission there by affecting the functionality of brain. The actual cause of it is not known, attributing to various reasons like the environmental, genetic. If we consider genetics of the disease, literature talks that there are approximately 23 PARK genes, of which we have considered PARK7, PINK, LRRK2 and their interactions with few active Thio heterocyclic compounds. And it is found that the LRRK2 and (4-aminophenyl) sulfanyl-4- hydroxychromen-2-one interacts well and holds a promising compound for further an invitro analysis.
Keyword :
Parkinson disease, alpha-synuclein, PARK, LRRK, PINK genes, heterocyclic compounds