Abstract :
The objective of the study was to develop naproxen sodium SR tablets were prepared by direct compression method
using hydroxy propyl methyl cellulose (HPMC K 100). To know the effect of polymer concentration invitro study
performed it has been observed that as the polymer concentration increases, the drug release rate decreases, and
bioavailability study carried out in healthy human subject by administering the developed sustained release and
marketed immediate release tablet. The developed naproxen sodium showed confirmed longer time to reach peak
concentration than marketed immediate release table, controlled and constant drug delivery system, maintains
better plasma concentration than conventional tablet by which it overcome the shortcoming of conservative
treatment. The rate and extent of absorption of naproxen sodium SR tablets were higher than the marketed
immediate release tablet shows more competent and controlled drug release which would sustain plasma
concentration level throughout and produce desired effect. Further evidenced with lower elimination rate and
higher half life.
Keywords: Naproxen sodium SR tablets, Marketed immediate release tablet, HPMC, LCMS-MS, Bioavailability
study
Keyword :
Naproxen sodium SR tablets, Marketed immediate release tablet, HPMC, LCMS-MS, Bioavailability study