Abstract :
Introduction: Liver biopsy contributes greatly to the understanding of liver diseases & is considered gold
standard for evaluating liver disorders, providing information regarding diagnosis, disease progression and
response to therapy.
Objectives: 1). To study histomorphological features of liver biopsies and to correlate them with presenting
co mplaints & radiological findings. 2). To document the pattern of various hepatic lesions.
Results/Observations: A retrospective study of 66 liver biopsies during the period January 2013 to May
2015 was done. Sections were stained with H & E and examined under light microscope. Special stains
were done in specific cases.
Among these, 45 cases were males and 21 cases were females. Out of 66 cases, 24(36.3%) cases were
hepatocellular carcinoma, 13(19.69 %) cases of glycogen storage disorder, 3(4.54%) cases each of fatty
liver, hepatitis, cirrhosis & degenerative liver disease. 2(3.03%) cases of liver cell dysplasia and 1(1.51%)
case each of biliary atresia , amyloidosis, miliary tuberculosis and liver abscess. Liver biopsy was non
specific in 4(6.06%) cases & inadequate in 7(10.6%)cases.
Conclusion: Microscopic examination of liver biopsy yields a diverse range of pathological findings and
helps to uncover diseases for which specific management is indicated.
Keyword :
Hepatocellular carcinoma, Glycogen Storage Disorder, Liver biopsy.