Abstract :
Introduction: Colorectal carcinomas are global oncologic problem faced by medical fraternity as it is the
third most common carcinoma in men after lung and prostate carcinomas also second in women after breast
carcinoma worldwide. 1998 to 2003, and the death rate decreased from 2.8% annually over the period 2001
to 2003. A great majority (98%) of all carcinomas in the colorectum are adenocarcinomas. The cause and
pathogenesis of colorectal carcinomas are related to both environmental and genetic factors. Both gross as
well as histopathological typing helps in definitive diagnosis and further management of the patient.
Materials and Methods: This one year retrospective study included forty-three (43) cases of colorectal
carcinomas. All the resected specimens received in the laboratory were immediately fixed in 10% formalin
for at least 24 hours. Gross features of specimen were noted and multiple representative sections were taken
for routine processing. After detailed study of sections under the light microscope the final diagnosis was
given along with disease stage (Dukes classification). The patient details like age, sex, clinical diagnosis
were obtained from the requisition forms that were sent along with the specimen.
Results: There were total of forty-three (43) patients of colorectal carcinomas during the study one year.
Male to female ratio was 1.15:1. Majority of the patients belonged to the age group of 58-67 years.
The most common malignancy was adenocarcinoma followed by mucinous carcinoma and neuroendocrine
carcinoma. The most common anatomical site involved was rectum.
Conclusion: This study concludes that colorectal carcinomas are more common in 5th and 6th decade of
life with slight male preponderance. The most common malignant lesion being moderately differentiated
adenocarcinomas. The most common location being rectum with highest incidence of Dukes stage B. The
histopathological examination remains the gold standard for the diagnosis and further management.
Keyword :
Colorectal carcinomas, Adenocarcinoma, Dukes Staging.