Abstract :
Matrix metalloproteinases (MMPs) constitute of different zinc containing enzymes which break down specific extracellular matrix components destroying matrix equilibrium and structural integrity. MMPs have multiple different actions in tissues. MMPs are mainly produced by multiple host cells like fibroblasts, inflammatory cells,epithelial cells. Balance between the production of MMPs and its inhibitors are essential to maintain the normal physiologic structure of host tissues. Overproduction of MMPs might lead to pathological conditions. Though MMPs are secreted less in quantity, it can be an useful biomarker for the detection and to know progression of periodontal diseases.
Keyword :
Matrix metalloproteinases, Extracellular Matrix, Periodontal Disease, Biomarker