Abstract :
Pharmacokinetics and toxicodynamics are two essential pillars in understanding the therapeutic potential and safety profile of drugs. Pharmacokinetics focuses on the absorption, distribution, metabolism, and excretion (ADME) of drugs, providing insights into how the body processes a substance over time. In contrast, toxicodynamics examines the biochemical and physiological effects of drugs on the body, particularly at toxic concentrations. Achieving an optimal balance between efficacy and toxicity is a critical challenge in drug development, as the therapeutic dose must be carefully balanced against the risk of adverse effects. This article explores the intricate relationship between pharmacokinetics and toxicodynamics, highlighting the need for integrated approaches to predict and mitigate toxicity while maximizing therapeutic benefits. We discuss current methodologies, emerging technologies, and predictive modeling techniques used to assess both efficacy and safety profiles, emphasizing the importance of personalized medicine and dose optimization in reducing the risk of toxicity. By understanding the interplay between these two domains, researchers and clinicians can enhance drug development, improve patient outcomes, and minimize adverse drug reactions.
Keyword :
Pharmacokinetics, Toxicodynamics, Drug Efficacy, Toxicity, Absorption, Distribution