Abstract :
The pharmaceutical dosage form manufacturing process use some of polymers, which contains traces of inorganic elements like Tin (Sn) content. The traces of inorganic elements were determined by using inductively coupled plasma mass spectroscopy (ICP-MS). It is a sensitive method used to determine the inorganic elements by atomic mass value. In the present study Tin (Sn) was extracted by the sample using microwave-assisted digestion with hydrochloric acid. Different validation parameters were employed to evaluate the method in terms of selectivity, specificity, method precision, accuracy, intermediate precision and standard measurement uncertainty. The mass value of tin element is 118 as per the Perkin Elmer instrument recommendations. The results indicate that this method could be used for the routine measurement of tin (Sn) in the pharmaceutical laboratories.
Keyword :
Analytical Method development, Analytical Method validation, Inductively coupled plasma mass spectrometry and Tin