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Prediction of insulin resistance by triglyceride glucose (TyG) index versus log (TG)/HDL-C Indices in non-diabetic participants


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Article type :

Original Article

Author :

Kwadjo Anicet Luc Déré, Kahissié Manhan, Seguenan Fofana, Gnomblesson Georges Tiahou

Volume :

12

Issue :

1

Abstract :

Introduction: Insulin resistance (IR) syndrome, is described as being the primum movens of several pathologies and having a close link with numerous diseases. Glucides metabolism impairment mostly encompassed by lipid disorders is found in pre-diabetic patients, and even in normoglycemic ones. Materials and Methods: We carried out this study for approximately one year. All volunteers above 18 years were eligible to participe. For participants naive of diabetes, blood samples were taken in different tubes for each intended analyses after 10 to 12 hours of fasting from the day before. Standard analyses (fasting glucose, total cholesterol, triacylglycerols, HDL cholesterol) have been run and we also registered anthropometrics parameters to calculate TyG and modified TyG ratios along with athorogenic index of plasma (AIP). Results: 33% of participants had a TyG index above the normal range. Meanwhile, a positive statistical correlation have been highlighed between mean values of AIP, TyG BMI and TyGWC with TyG index for mean values more and more elevated. A positive statistical correlation has been found between TyG BMI and AIP, TyG index and TyGWC, similarly TyGWC with different biochemical parameters investigated showed a sustainable increasing of the mean value of fasting glyceamia, triacylglycerols, total cholesterol and LDL cholesterol. Concerning AIP index, 76% of participants had a mean value over 0.11 and within them 64% had a mean value above 0.21. AIP index was positively correlated with other biological parameters including TyG index, TyGBMI and TyGWC but not with BMI and Waist circumference. Conclusion: its emerges that moreover clinical set tools, for instance HOMA-IR, the TyG index along with its modified trygliceride indices should be a good routinely indicator for insulin resistance. Nonetheless, It should be important to implement such a study on a larger population and carry out studies in conjunction with HOMA-IR in the same conditions.

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