Author :
Muhammad Danish Mehmood, Ehsan Ali, Huma Anwar Ul-Haq, Rabia Habib, Muhammad Ismail, Fareeha Arshed
Volume :
12
Issue :
1
Abstract :
The project aimed to evaluate ten Indigenous isolates of the Infectious Bursal Disease (IBD) virus using in silico methodologies, including phylogenetic analysis, homology modelling, and molecular dynamics simulations. The study focused on understanding the physiological and chemical properties of the viral surface target proteins, the interactions between proteins and ligands, and the stability of various protein-ligand complexes. The results revealed differences in stability and interaction patterns among the complexes, highlighting the significance of specific residues and secondary structural elements. These findings provide valuable insights into the behavior of the viral isolates and their potential impact on Bursal Disease. The abstract emphasizes the need for future research to build on these findings to enhance our understanding of IBD genetic diversity and improve disease control measures by developing effective homologous vaccines.
Keyword :
">