Abstract :
Objective: Vitamin D mediates a pivotal role and major risk factor in the development of type 2 diabetes
mellitus mediated by alteration in the insulin sensitivity or b -cell physiological function, or both. The
present study was carried out to analyze the serum levels of vitamin D3 in type 2 diabetics on insulin
sensitizers and in newly diagnosed diabetics.
Materials and Methods: In this 100 subjects were enrolled and they are divided in two groups, newly
diagnosed type 2 diabetics and type 2 diabetics on insulin sensitizers. Serum vitamin D3 was measured by
chemiluminescence microparticle immunoassay. Fasting plasma glucose level was measured by hexokinase
method using the Dimension clinical chemistry system.
Results: In this study, the mean serum vitamin D3 level was significantly (p
type 2 diabetes mellitus subjects as compared to the type 2 diabetics on insulin sensitizers (10.332.56 vs
20.89 3.24 ng/ml)s. Further, in patients who were on treatment with insulin sensitizers showed normal
level of Vitamin D3 and Fasting blood glucose. Conclusion: Thus, vitamin D3 deficiency is the hallmark
status in diabetes mellitus and maintenance of type 2 DM with insulin sensitizers may ameliorate the
vitamin D deficiency.
Keyword :
Type 2 Diabetes, Blood glucose level, Vitamin D.