Abstract :
Introduction: Diabetes Mellitus is one of the world’s leading non communicable public-health problems.
It is a endocrine disorder resulting either from absolute deficiency of insulin or their is resistance to insulin
action. g - Glutamyl Transpeptidase ( GGT) might reflect metabolic disorder and could serve as a marker
for insulin resistance. Raised serum GGT activity which is observed in these diabetic patients is in response
to increased apoptosis and oxidative stress that occurs during the course of the disease. Thus, this study
was performed to examine g - Glutamyl Transpeptidase as a useful bio marker for the detection of type 2
diabetes mellitus.
Materials and Methods: A total of 250 individuals were selected from the OPD, medicine department
at ESIC hospital, Okhla and 250 normal healthy adults were selected as controls. The data was collected
from a period of over 8 months i.e. March 2018 till October 2018.
Result: The study showed higher levels of glycosylated hemoglobin (HbA1c), GGT and malondialdehyde
(MDA) levels in the study group when compared to control group. The increased levels of GGT are
associated with insulin resistance, oxidative stress and also involved in the development of type 2 diabetes
mellitus.
Conclusion: Study suggested the levels of Fasting Blood Sugar, Post Prandial Blood Sugar, HbA1c, MDA
and GGT increased in the DM type 2 patients as compared with that of normal persons. Hence, GGT which
is a marker of Oxidative stress was also raised in cases of DM type 2.
Keyword :
Diabetes mellitus type 2, Gamma Glutamyl Transpeptidase, Glycosylated hemoglobin, Oxidative stress, MDA.