Abstract :
Introduction: Thyroid disorders are one of the most prevalent endocrinopathies across the globe. As
per the data of India Government, the prevalence of hypothyroidism is about 5.4%. Hypothyroidism is a
common endocrine disorder encountered in clinical practice. Hypothyroidism (both clinical & subclinical)
has been reported to be associated with inflammation, dyslipidemia which leads to CV risk. Hs-CRP is
a marker of chronic subclinical inflammation and a predictor of CVD. The mechanism responsible for
inflammatory process seen in hypothyroidism might be TSH induced produced production of TNF-a by a
bone marrow cells.
Aims and Objectives: To analyse the thyroid profile, hs-CRP and lipid profile in newly detected
hypothyroid adults in comparison to controls and also to compare the above parameters in subclinical
and clinical hypothyroid cases.
Materials and Methods: A total of 164 subjects (82 hypothyroid cases and 82 euthyroid (controls),
visiting General Medicine OPD, RRMCH, Bengaluru were consider for study. The subjects were selected
based on thyroid profile-analysed by CLIA, hs-CRP by Immunoturbidimetric, Lipid profile was measured
by spectrophotometric method. Statistical analysis was done using student’s “t” test and Pearson’s
correlation.
Result and Discussion: The study subjects were age matched (mean age 35 years) with female
predominance. TSH value significantly increased in cases (p within the reference range. Serum hs-CRP levels though significantly increased in cases (p=0.005), were
within the normal range. There was significant increase in LDL-c and TG (p (p positive correlation was found between TSH and hs-CRP (r=.275, p
Keyword :
hs-CRP, Thyroid stimulating hormones, Clinical hypothyroidism, Subclinical Hypothyroidism.