Abstract :
Introduction: The Present study aimed to assess the effect of levothyroxine replacement therapy on serum lipid profile and thyroid function parameters of patients on subclinical hypothyroidism. We also aimed to correlate the lipid profile parameters with body mass index.
Methods: Ninety patients of subclinical hypothyroidism treated with levothyroxine for three months were included in the study. Fifty three euthyroid subjects served as controls. Levels of serum TSH, total cholesterol were assayed before and after levothyroxine therapy in patients with subclinical hypothyroidism. Levels of serum TSH, total cholesterol, LDL-cholesterol, HDL-cholesterol, T3 and T4 in subclinical hypothyroidism patient’s post-levothyroxine therapy were compared with those of euthyroid controls, and correlated with body mass index.
Results: The study demonstrated significant decrease in serum total cholesterol levels in subclinical hypothyroidism patients on levothyroxine treatment (P
Keyword :
Subclinical Hypothyroidism; Levothyroxine; Lipid Profile; Body mass Index