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Article type :

Original Article

Author :

Ashish Prakash Anjankar, Prashant Vasantrao Dharme, Rajesh Kawaduji Jambhulkar

Volume :

4

Issue :

2

Abstract :

Introduction: As kidney functions deteriorate, lipid profile abnormality begins. In kidney disease, more lipoprotein synthesis than its degradation results in dyslipidemia, which increases the risk of atherogenesis. The present study was aimed to study the lipid abnormality pattern in chronic kidney disease patients and to study the role of hemodialysis in management of these patients. Methods: 100 diagnosed chronic kidney disease patients [50 cases undergoing hemodialysis (HD) and 50 controls i.e. managed on conservative line without dialysis] were enrolled for the study after institutional ethical committee’s clearance was obtained. In this study, we measured serum lipid profile comprising of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C) and atherogenic ratios (LDL-C/HDL-C, TC/HDL-C). Results: In our study, we found that the mean values of TC, TG, LDL-C, VLDL-C and atherogenic ratios (LDL-C/HDL-C, TC/HDL-C) were significantly lower and HDL-C was significantly higher in cases of hemodialysis group than the corresponding values in the control group. Conclusion: Hemodialysis results in improvement in lipid abnormalities in the patients with chronic kidney disease. Therefore, hemodialysis can be started early in the chronic kidney disease to retard the progression of atherosclerosis.