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Article type :

Original Article

Author :

Prakash S. Hundekar, Adinath Suryakar, Aarti Karnik, Rahul Ghone, Sonali Bhagat

Volume :

4

Issue :

1

Abstract :

Background: Sickle cell anaemia (SCA) is a hereditary disorder, associated with severe haemolytic anaemia, periodical vasooclussive pain, and premature death. Prevalence of SCA is alarmingly high in north Maharashtra comprising districts of Nandurbar, Dhule, Jalgaon and Nashik. Non heme iron and depleted erythrocytic glutathione are associated with generation of free radicals leading to oxidative stress. Oxidative stress may enhance haemolysis by damaging erythrocytic membrane. Aim and Objectives: To evaluate serum iron, erythrocytic MDA and erythrocytic Glutathione in relation with possible markers of oxidative stress in the steady state of SCA individuals. Methods: A total of 90 subjects were recruited in the study including 30 sickle cell trait (HbAS), 30 sickle cell disease (HbSS) and 30 healthy controls. In all subjects serum iron and bilirubin, erythrocytic Malondialdehyde (MDA) and glutathione (GSH) concentration were investigated simultaneously. Results: Serum iron level found significantly (p