Abstract :
Background: Rheumatoid arthritis is one of the chronic inflammatory disease affecting joints and other organs is primarily of an unknown etiology with an incidence of 1% to 2% of total world population.one of the current school of thought implies oxidative stress related to free radical damage, auto immunity and genetic predisposition are few of the important etiological factors proposed for its causation. The current study is aimed to see whether detection of lipid peroxidation products such as Malondialdehyde(MDA) and estimation of serum calcium, phosphorous, Alkaline phosphatase, calcium-phosphorous ratio as biomarkers for Rheumatoid Arthritis that will help to diagnose and treat disease at an early stage.
Material and Methods: The current study is prospective study carried out at Kakatiya Medical College and Mahatma Gandhi Medical College, Warangal from January 2014 to January 2015 over 100 subjects of which 50 cases were suffering with Rheumatoid arthritis while 50 subjects were normal healthy adults. Data was recorded in a pretested proforma and was analyzed using appropriate statistical methods.
Results: During the study, it is found that there is raise in mean MDA levels in the group suffering with Rheumatoid arthritis (p value
Keyword :
Malondialdehyde (MDA), Rheumatoid Arthritis, Serum Calcium, Serum Phosphorous, Calcium-Phosphorous ratio