Abstract :
Diabetes Mellitus (DM) is an important cause of morbidity and mortality through its various complications. A decrease in Paraoxonase 1 (PON1) activity in diabetes is associated with occurrence of vascular complications. Our objectives were to estimate PON1 activity, Catalase (CAT) activity and Malondialdehyde (MDA) levels in Non-Insulin Dependent Diabetes Mellitus (NIDDM) cases and controls. We also had an objective to establish possible relationship between PON1, High Density Lipoprotein-Cholesterol (HDL- Cholesterol), CAT, MDA levels and to correlate CAT/PON1 ratio with Glycosylated Hemoglobin (HbA1c) levels.
Keyword :
Diabetes Mellitus, Paraoxonase, Oxidative stress, CAT/PON1 ratio