Abstract :
Background: Due to the increased relevance of renal impairment in hypertension in developing countries like India,this study was undertaken to evaluate the serum levels of cystatin C in essential hypertensive patients. A correlation between the degree of hypertension, serum cystatin C and Glomerular Filtration Rate(GFR) was also assessed to prove the superiority of cystatin Cover creatinine to detect renal impairment at an early stage.
Materials and Methods:160 subjects were enrolled in the present study.80 hypertensive patients with 36 in stage I and 44 in stage 2 were diagnosed according to JNC VII criteria.80 age and sex matched healthy normotensive controls were included. The levels of cystatin C, urea, creatinine, uric acid, and serum electrolytes were measured.
Results: The mean serum cystatin C in hypertensive patients(1.11±O.25 mg/l) was found to be significantly raised(p
Keyword :
Essential hypertension, Renal impairment, CKD, Cystatin C