Author :
Viyatprajna Acharya, B D Toora
Volume :
2
Issue :
1
Abstract :
Background: Obesity is now occurring in pandemic proportions and has earned a new name as “Globesity” for it. Unlike earlier times developing countries too are facing the challenge of obesity and the modern epidemics have a common root cause tapering to obesity. Obesity during adolescent and young adulthood usually persists to adulthood in almost 50% cases and gives rise to early onset of type 2 diabetes mellitus, cardiovascular disorders and metabolic syndrome for which insulin resistance being the common link to all.
Objective: The present study was taken up to study the prevalence of insulin resistance in apparently healthy young adult obese population and study its correlation with different cardiovascular risk factors like lipid profile and sdLDL-C.
Material and Methods: In a randomized control study 106 apparently healthy young adults in the age group of 21-34 years were chosen from the community out of which 45 were obese and 61were age and gender matched non-obese controls. They were divided in obese and non-obese groups based on cut-off BMI of 25Kg/m2. Along with physical parameters fasting plasma glucose, lipid profile and routine biochemical parameters were assayed by standard kit methods and plasma insulin was measured by sandwich ELISA method. Different lipid ratios, atherogenic index and insulin resistance were calculated. Atherogenic index was calculated and insulin resistance was measured by HOMA-IR model and QUICKI index. Small dense LDL-C (sdLDL-C) was quantified by modified Tsutomu –Hirano method.
Results: In the obese group BMI, waist circumference (WC) and waist-hip ratio (WHR) elevated significantly (p=0.0001) and TG, VLDL-C and sdLDL-C as well as atherogenic index elevated significantly (p