Abstract :
Introduction: Pain and inflammation are a day to day affliction for all living beings. Mankind has for years been trying to relieve the agony of pain & inflammation through various means with a large amount of success. Still we have not been able to produce the ideal analgesic or the ideal anti-inflammatory drug. The objective of this study was to evaluate a saponin, albichinoside, with respect to its ability to relieve pain and /or show anti-inflammatory activity.
Materials and Methods: The study was conducted on rats. The saponin was evaluated for its effects on acute, sub-acute, chronic and immunological inflammation by using standard anti-inflammatory study protocols.
Results: The test substance showed significant inhibition of acute, sub-acute and chronic inflammation produced by immunological and non-immunological methods in rats. These activities were qualitatively less as compared to indomethacin. This activity was like that of non-steroidal anti-inflammatory agents.
Conclusion: The test substance has moderate anti-inflammatory activity which could be by means of inhibition of prostaglandin synthesis and the complement.
Keyword :
Saponin, Anti-inflammatory, Animals.