Abstract :
Introduction: Lesions of urinary bladder constitute an important source of clinical signs and symptoms.
Both neoplastic and non-neoplastic lesions do occur commonly, however the former being the most
common type. Majority of urinary tract tumors are epithelial in origin, among which 90% of them are
urothelial in origin.
Objective: To evaluate the histopathological spectrum of urinary bladder lesions with emphasis on the
neoplastic lesions with reference to 2016 WHO classification of tumors of urinary system.
Materials and Methods: This was a prospective study and includes all the urinary bladder specimens
received. They were examined grossly and processed completely as per the standard procedure. Multiple
sections of 3-5microns were taken and stained with H&E, followed by light microscopic examination to
study various non-neoplastic and neoplastic lesions.
Results: Total 65 cases were studied, 30 were cystoscopic biopsies and 35 were TURBT specimens. There
were 40 males and 25 females constituting up to 61.54 % and 38.46 % respectively. Chronic non-specific
cystitis was the common non-neoplastic lesion. Among neoplastic lesion, Invasive urothelial carcinoma
was the predominant lesion constituting 22 cases (62.86%). These neoplastic lesions were more common
among males (74.28%) with M:F ratio of 2.8:1.
Conclusion: Urinary bladder lesions are most frequently encountered by surgical pathologists and are
heterogenous. Both benign and malignant lesions are well documented but latter being more common.
Many of these are more common in elderly people with male predilection and are often associated with
smoking. Identifying the extent of invasion by microscopic examination constitutes an important aspect in
urothelial carcinomas.
Keyword :
Urinary bladder, Cystoscopic biopsy, Transurethral resection of bladder, tumor, Invasive urothelial carcinoma.